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Some may require more sessions, due to many years of medication use and overall poor health that contributes to years of constipation
Here are the general guidelines: Administer one injection subcutaneously (under the skin) once a week, on the same chosen day each week
doi: 10.1111/bph.14585 70 MedalaVKGollapelliBDewanjeeSOgunmokunGKandimallaRVallamkonduJ
Most patients find that the medication becomes much easier to tolerate once they reach a stable maintenance dose
If you have plateaued at lower doses, completing your titration should be the first intervention
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