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Topical application does not typically cause systemic side effects
However, further work is necessary to determine the optimal dosing, delivery route, and safety for these treatments before they can be used clinically (Galdiero et al., 2020
So, if youre feeling hungry following creatine use, rest assured you are not alone and are in the right place to understand why there might be a connection
Mechanistically, -KG decreases Treg differentiation by inhibiting FOXP3 and upregulating inflammatory cytokines such as IFN-, Tbet, and Rorc, suggesting that Th1-type effector T cells are more dependent on glutaminolysis than Treg cells 136
It contains antioxidants that may help remove toxins and free radicals, potentially contributing to a healthier appearance
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