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This is referred to as the maintenance dose, as it is the dose you work up to over the course of weeks to reach and is maintained going forward
Therefore, the authors hypothesized that the beneficial effect exerted by BMSCs in the nervous system might depend on HGF secretion and on HGF-MET axis activation ( Mesenchymal stem cell transplantation exerts a beneficial role also in the EAE mice, the animal MS model, promoting a functional recovery ( 2+ levels by the modulation of calbindin expression, which is associated with calcium homeostasis and plays a role in the protection of dopaminergic neurons in the pathogenesis of PD ( The influence mediated by HGF secretion and HGF-induced MET activation in all these studies provides an evidence that, beyond stem-cell ability to differentiate into neurons, the secretion of paracrine growth factors such as HGF provides an important regenerative capacity and a promising therapeutic tool
placebo 22%), although this did not reach statistical significance
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DSIP is a low-molecular-weight amphiphilic nonapeptide the selective membrane that separates circulating blood from brain tissue
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