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Six-to-12 months later, the patients were asked to recall if their pain had improved

Notably, curcumin, a polyphenolic compound derived from turmeric, has been reported to synergize with azoles and polyenes to amplify ROS generation in Candida albicans , leading to mitochondrial damage, apoptosis, and enhanced antifungal activity (Sharma et al., 2010b

Side effects are usually mild and limited to skin sensitivity, irritation, or sun sensitivity

The treatment normalized serum corticosterone levels, enhanced central GABA and serotonin concentrations and reduced peripheral inflammation and gut microbiota profiling revealed a reduction in potentially pathogenic genera ( Acinetobacter, Enterococcus, Bacillus ) and increased abundance of beneficial taxa ( Muribaculum, Alistipes, Lactobacillus ), indicating the therapeutic potential of targeted psychobiotic intervention for stress-related disorders (Tyagi et al., 2025)