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Current evidence supports the safety profile of GLP-1 medications when prescribed appropriately, with benefits in glycaemic control and cardiovascular risk reduction generally outweighing theoretical thyroid concerns for most patients
National Preferred Formulary 2026
According to one large study in 9,075 people, having higher blood levels of vitamin B12 was associated with a lower risk of obesity ( Similarly, another study in 976 people showed that having low levels of vitamin B12 was linked to a higher risk of overweight or obesity ( Whats more, a study in 256 children showed that children with lower levels of vitamin B12 tended to have a higher body mass index (BMI), which is a measure of body size determined by height and weight ( However, keep in mind that while these studies show an association between vitamin B12 status and body weight, they dont take other potentially contributing factors into account
Until larger human trials are available, most clinicians recommend empty-stomach administration for both oral and sublingual routes
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