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Phase 2 data showed 24.2% weight loss at 48 weeks with the same dose

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Retention of this unmodified histidine in retatrutide preserves potent glucagon receptor agonism, which is a defining structural distinction compared to tirzepatide, where this position is also histidine but the molecule lacks meaningful glucagon receptor activity due to other sequence differences

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When considering product positioning of each brand, a wide range of dimensions can be considered to fit the positioning within a companys portfolio and the competition (see Table 3)

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