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From the preclinical data for putative benefits there were also important side effects noted
doi:10.1016/s0140-6736(12)61084-8 63Williams JG, Alam MF, Alrubaiy L, et al
Some GI adjustment (mild nausea, fullness) is normal and passes within 2-4 weeks
Previous work has shown that the abundance of Lactobacillus reuteri (normalized to a control group) decreases during the onset of obesity and remains suppressed even after dieting in mice 99 , which parallels our observations that vehicle-treated diet-switched mice had lower levels of Lactobacillus than the 5A-1MQ-treated mice, the latter of which also demonstrated greater weight loss
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