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Edited by Professor Alessandro Finazzi-Agr Supplementary information Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made

Clinicians should carefully consider individual patient characteristics, especially in those with preexisting gastrointestinal conditions, when selecting GLP-1RAs and adjusting dosages

PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells

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Chronic inflammation and persistently elevated glucose levels are common threads in cardiovascular disease, cognitive decline, and certain cancers