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Our findings demonstrate that SLC25A39 plays a critical role in maintaining mitochondrial homeostasis and HCC progression, and its knockdown activates a caspase-dependent apoptotic pathway through the mitochondrial ROScytochrome c pathway, inhibiting the proliferation, migration, and invasion of HCC

(2016a) observed that upregulation of Metallothionein 1G (MT-1G) by Nrf2 led to resistance of HCC cells to sorafenib

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