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In HIV-related research, daily tesamorelin reduced deep belly fat meaningfully versus placebo, but it works best for body composition, not big weight loss numbers
Neurological Symptoms: Numbness, tingling, or weakness not related to the injection site
But the mere presence of the enzyme does not guarantee its high activity
Other medications commonly prescribed alongside GLP-1 therapy may contribute to erectile difficulties: Antihypertensives : Beta-blockers and thiazide diuretics are recognised causes of ED Antidepressants : Selective serotonin reuptake inhibitors (SSRIs) frequently impair sexual function 5-alpha-reductase inhibitors : Finasteride and dutasteride for prostate conditions can affect sexual function Antipsychotics : Can impact sexual function through various mechanisms Opioids : May reduce testosterone levels and affect sexual desire and function Spironolactone : Can cause hormonal effects that impact erectile function The relationship between statins and erectile function is complex, with mixed evidence
tirzepatide trials extended to 72 weeks Population size: Phase 2 trials have smaller participant numbers Protocols: Different study designs and endpoints Reported Adverse Events The 2025 meta-analysis reported on adverse event frequency from the published trial data: The meta-analysis noted that adverse events were more frequent with retatrutide (RR 4.10) compared to tirzepatide (RR 2.78)
