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The findings of a large US real-world cohort (n= 18,000) study, published in 2024, show that patients on tirzepatide were significantly more likely to achieve 5 %, 10 % and 15 % weight loss compared with semaglutide (HR 1.76, 2.54, 3.24, respectively), with a 12-month mean weight difference of -6.9% 8
This twice daily injectable established the entire drug class
however, following Wegovy's 2024 cardiovascular risk reduction indication, Medicare Part D plans may cover Wegovy when prescribed specifically for this cardiovascular indication in eligible patients
In a head-to-head study (SURPASS-2), Mounjaro topped Ozempic (1 mg semaglutide), showing it was more effective in helping patients keep their blood sugar levels in check and lose weight
In 1980, a young gastroenterologist named Jean-Pierre Raufman wound up taking the latter road through the digestive-diseases branch of the National Institutes of Health
