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The honest caveat is important: much of the evidence for these peptides is still preclinical, meaning animal and laboratory research, so they are best understood as a supervised, supportive option with realistic expectations rather than a proven cure

Lipidomic analysis of hepatocytes with different ApoE genotypes revealed that ApoE 4 may promote systemic metabolic imbalance by interfering with lipid distribution, glucose metabolism, and adipose tissue inflammation [84]

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Citation: Howard et al., Science, 1996