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Moreover, manganese dioxide nanosheets loaded with Zebularine and surface-modified with hyaluronic acid to construct the nanoparticle Zeb@MH-NS can promote the accumulation of dsDNA in the cytoplasm upon reaching the tumor site, enhance the activation of the cGAS-STING signaling pathway, increase the production of type I interferons and the secretion of pro-inflammatory cytokines, and boost the maturation of DCs, the infiltration of CTLs, and the recruitment of NKs at the tumor site (231)

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We inferred that the lower expression of IGF1 protein would exhibit a delay exerting its function in male GM muscle, which might be less sensitive to IGF1 compared with female GM mice