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SCFAs attach to immune cells G-protein-coupled receptors (GPCRs), which regulates cytokine production and reduces inflammation

For that reason, it is more accurate to call copper a theoretical concern with prolonged exposure than to say that longer KLOW cycles are proven to cause copper buildup

If that holds up in prospective studies, it changes how we think about this disease entirely, and this finding provides a strong rationale for further mechanistic and clinical studies focused on endometrial cancer prevention and treatment. The most dramatic drops in risk, where this reduction was by 50% or more, also occurred in multiple myeloma, pancreatic cancer, and colorectal cancer, in addition to endometrial cancer

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