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Lastly, it is important to exercise caution when directly comparing detailed results between the main and exploratory cohorts, as well as between the 1st- and 2nd-year follow-up periods, because sample sizes differed due to varying inclusion/exclusion criteria and data availability
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How injectable/oral GLP-1 medications work: Mimic the GLP-1 hormone with engineered modifications for extended duration Bind to GLP-1 receptors to enhance insulin release and reduce glucagon Slow gastric emptying by 20-50%, promoting satiety Supported by large randomized controlled trialsthe STEP trials showed 14.9% mean weight loss at 68 weeks versus 2.4% for placebo The short answer on why patches cant deliver these drugs: GLP-1 molecules are relatively large peptide chains (molecular weight 3-5 kDa) that cannot effectively penetrate the skin barrier through passive transdermal diffusion
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