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Retatrutides Phase 2 monotherapy weight loss (~24.2% at 48 weeks) is numerically larger than cagrilintides (~10.8% at 26 weeks), but those come from different trials, durations, and doses, and cagrilintides strongest data are as the CagriSema combination

The most commonly reported side effects are gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, particularly during dose escalation

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There is also a sport-eligibility dimension clinicians are often unaware of

A role of the enzyme in modulating stress responses by controlling JNK activity was also proposed 56, 57