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Being overweight or obese is a serious health problem connected with some leading causes of death, including diabetes, stroke, and heart disease, and is associated with an increased risk of certain types of cancer

Eli Lilly has reported phase 3 data for orforglipron in its ATTAIN trial update, and AstraZeneca has advanced its candidate following midstage results reported in industry coverage

Simultaneous GLP-1 receptor activation in the hypothalamus reduces appetite signaling by delaying ghrelin rebound and prolonging the elevation of satiety hormones like peptide YY (PYY) and cholecystokinin (CCK)

Diallo M, Diadie S, Diatta B, et al

It promotes angiogenesis, the formation of new blood vessels, which accelerates nutrient and oxygen delivery to healing tissues