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Other common gastrointestinal effects include: Vomiting (5-24% of patients) Diarrhea (8-30% of patients) Constipation (10-24% of patients) Abdominal pain or discomfort (5-20% of patients) These side effects are typically most pronounced when initiating therapy or increasing doses, and often diminish over time as the body adjusts to the medication

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The practical problem on a GLP-1 is mechanical, not motivational: even when you intend to eat protein, early fullness and a slower-emptying stomach can stop you partway through a meal