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Patients with ongoing weight loss or certain medical conditions may be advised to wait before proceeding

Although gastrointestinal symptoms that occur after stabilization are unlikely to be drug related, such an occurrence of symptoms should be evaluated to determine if it may be due to lactic acidosis or other serious disease

However, those with severe bile acid diarrhea, active pancreatitis history, or advanced liver/kidney disease should defer treatment pending specialist evaluation and symptom optimization

These range from the potential for better weight loss results to each medication having a different side effect profile