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In a recent paper, published in the Journal of Biological Chemistry , our team in Yin Chen's lab at Warwick's School of Life Sciences focused on the CntA protein of the CntA/B enzyme, to stabilize and study it

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These biochemical adaptations result in a metabolic reprogramming that promotes lactate production and accumulation, thereby reinforcing the hypoxic cellular response

The heterozygotes were intercrossed to generate Glp1r / mice and their wildtype (WT) littermates