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So beyond its shelf life, theres a greater risk of contamination and bacterial or fungal growth in the liquid
A patient losing 15-20% body weight may require dose reduction to avoid iatrogenic hyperthyroidism
The efficacy advantage is significant an average of 5-7 additional percentage points of body weight lost and the side effect profile is comparable to semaglutide
It is currently under clinical investigation for the management of obesity and type 2 diabetes (as demonstrated in a phase 2 trial published in the New England Journal of Medicine), and as of the time of writing, it has not received marketing authorisation from the Medicines and Healthcare products Regulatory Agency (MHRA) or the European Medicines Agency (EMA)
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