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In the NEJM Phase 2 trial, participants assigned to an initial dose of 4 mg experienced significantly more adverse events than those who started at 2 mg, even when both groups ultimately reached the same target dose

The speed at which tirzepatide works surprises many users, with appetite changes often noticeable within the first week or two of treatment

Injections are often medically necessary for people with Crohns disease, Celiac disease, or those who have undergone bariatric surgery

Exposure to direct sunlight and extreme heat should be avoided

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