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Those scheduled for procedures requiring anesthesia should inform their healthcare team about semaglutide use due to its effects on gastric emptying
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Most are gastrointestinal and usually mild: Nausea (often improves after 24 weeks) Diarrhea or constipation Bloating or abdominal discomfort Reduced appetite (that one's the point) Fatigue in the first few weeks To minimize them: follow the titration schedule, eat smaller meals, go easy on greasy/high-fat foods, stay hydrated, and consider injecting at bedtime
Expect minor improvements in skin comfort, but visible change is still on the horizon
Most reputable suppliers use insulated packaging with cold packs for summer shipping, but the lyophilised form is chemically stable enough to survive standard ground transport
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