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It is noteworthy that clinical studies have revealed an upregulation in the expression of STAT3 within the intestinal mucosa of individuals suffering from IBD (Li et al., 2010)

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Through co-immunoprecipitation (CO-IP) experiments, we discovered that FOXO4-DRI prevents the binding of FOXO4 to P53, facilitating the phosphorylated P53 nuclear exclusion, which subsequently trigger BAX and cleaved caspase-3, leading to the apoptosis of senescent cells

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Synthetic peptides are manufactured to mimic or enhance these natural functions