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This indicates that their cardiometabolic benefits are primarily mediated by weight loss, IR alleviation, and improvements in triglyceride-rich lipoprotein pathways, rather than a direct reduction in LDL-C levels
PLoS One 9 (6), e98135
A separate retrospective study published in 2025 in JAMA Ophthalmology compared patients who took either oral or subcutaneous semaglutide for type 2 diabetes and matched them to control based on race, sex, A1c and comorbid conditions such as DR, sleep apnea, hypertension and hyperlipidemia
Blood collection and hormone analysis Blood samples were collected 23 hours after dark onset from the tail vein of mice that had ad libitum food access
That said, heres a quick comparison of Semaglutide, lifestyle changes, and surgery for managing PCOS
