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Emerging players advance differentiated mechanisms, including Pfizer's partnership for a phase 1 small-molecule agonist and Amgen's novel candidates
For Zepbound, 109 million people have lost their coverage, up 12% from last year
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In toxin-induced PD mouse models, DA-JC1, a novel dual GLP-1/GIP receptor agonist, improved motor impairment, increased the number of dopaminergic neurons in the substantia nigra, enhanced BDNF levels, and modulated apoptosis signaling pathways by altering the expression of Bax and Bcl-2 [89, 90]
