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Lotz-Havla AS, Wei KJ, Schiergens KA, Brunet T, Kohlhase J, Regenauer-Vandewiele S, Maier EM

Patients with severe hepatic or renal impairment may require special consideration, though specific dosing guidelines for these populations have not been established

Some individuals report dramatic improvement within the first 3 days, describing reduced pain during movements that were excruciating just days before