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J Agric Food Chem 59:89088914
9:e101815
It is about whether patients have a medical reason that an FDA-approved version cannot meet for example, an inactive-ingredient allergy or a documented need for a different formulation
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A 12-week study in humans where participants were given 500mg of berberine 3 times a day resulted in: an average weight loss of 5lb (2.3kg) a 23% reduction in triglycerides (a type of blood fat) a 12.2% reduction in cholesterol However, animal studies show that berberine has a very low bioavailability of less than 1% (how much of it is absorbed in your bloodstream), which may affect its effectiveness
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