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Wegovy Contrave (naltrexone/bupropion): Contrave is a combination of naltrexone, which is used to manage substance use disorder, and bupropion, an antidepressant that also helps with smoking cessation
Participants had a baseline body mass index (BMI) 30 or 27 with one or more obesity-associated comorbidities including hypertension, insulin resistance, sleep apnea, or dyslipidemia
Finally, a pooled analysis of RCTs and open-label phase III studies showed that once-weekly exenatide reduced albuminuria 26% (95% CI%: 39.5 to 10%) compared with comparators (Van Der Aart-Van Der Beek et al., 2020)
Liraglutide and semaglutide have shown efficacy in reducing the -synuclein load in the chronic MPTP mouse model of PD [81]
Disclaimer: Semaglutide and tirzepatide are prescriptiononly medications provided when clinically appropriate under medical supervision
