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Tirzepatide is indicated to reduce excess body weight and maintain weight reduction long term in adults with obesity or adults with overweight in the presence of at least one weight-related comorbid condition. Both documents put long term inside the indication itself

The study also showed several cardiometabolic benefits of semaglutide with significant improvement in hemoglobin A1C, body weight, and cholesterol reduction compared to placebo

Fat loss still depends on overall calorie balance, activity level, and consistency

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