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2 Materials and methods 2.1 Animal studies Seipin knockout (SKO) mice with germline disruption of the Bscl2 gene were generated as previously described on a C57BL/6J background ( ad libitum access to water and food consisting of a standard rodent chow diet (CRM (P) 801722, Special Diets Services)

Patients on dialysis generally require higher protein intake (1.01.2 g/kg)