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Its approval rests on two multicenter, randomized, double-blind, placebo-controlled trials in patients with erythropoietic protoporphyria one conducted in Europe and one in the United States in which the afamelanotide implant increased the amount of pain-free time patients could spend in sunlight and was generally well tolerated, with adverse events that were mostly mild
In the case of topically applied caffeine, its delivery could be shown after only 5 minutes, but only with open hair follicles
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Additionally, in the adipose tissues of animals treated with AOD 9604, increased lipolytic activity was noted
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