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Experimental literature on excess SAM also supports the idea that methylation balance is not governed by SAM alone

B12 is a water-soluble vitamin your body uses to: Make red blood cells (which carry oxygen to your tissues) Keep your nervous system functioning properly Help your body turn food into usable energy Your body can't make B12 on its own you get it from animal-based foods (meat, eggs, dairy) or supplements

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It has an hepatic metabolism, mainly because of the glucuro-conjugation of the molecule, with the formation of inactive metabolites