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Tirzepatide the active ingredient in Mounjaro and Zepbound mimics GLP-1 and GIP, another appetite-suppressing hormone

The associated SNP, rs10305420, is a missense variant in the signal peptide of the GLP1R gene, changing the seventh amino acid from proline to leucine (p.Pro7Leu)

It is therefore not available as a licensed medicine through the NHS or private prescribing channels in the UK

An oral tablet is accessible regardless of manual dexterity, removing a practical barrier that disproportionately affects older populations