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Additionally, two small studies in participants presenting with antiretroviral-induced neuropathy found significant reduction in subjects' mean pain intensity with oral ALCAR (1-3 g/day) for 4 to 24 weeks, but no effect on objective neurophysiological parameters was found (82, 83)

In 2023 the FDA placed BPC-157 in Category 2 of its 503A bulk-substances review the group flagged as presenting significant safety risks for compounding reflecting concerns about immunogenicity, impurities, and lack of human data

This includes issues like heart disease, nerve damage, and kidney problems