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2 people out of 100 who received drug X experienced a heart attack after 3 years 4 people out of 100 who received the placebo experienced a heart attack after 3 years We divide 4/100 to get the baseline absolute risk in this placebo group (often referred to as the control group), which is 4% We then divide 2/100 to get the absolute risk in the group taking the medication (often referred to as the exposure or intervention group), which is 2% To understand the relative risk, we divide the exposed group with the placebo group: 2%/4% = 50% We can then calculate the difference between 2% and 4% to understand the absolute risk, which would be 2% This means that drug X causes a 50% relative drop in the rate of heart attacks compared to the placebo group

The ANOVA for this response variable is shown in Supplementary Table 6 , where a p-value for the model is explained by the linear term

Eur J Clin Invest 22: 283-291, 1992

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The reason for this effect may be that even a 90% depletion of hepatic GSH levels, as observed after an APAP overdose [91] , still leaves enough GSH (0.5-1.0 mM) as a cofactor for this enzyme activity