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A detailed description of the methods used to derive transition probabilities is provided in ESM Methods
Slowed motility in the small intestine and colon contributes to constipation and to altered gas production
Eli Lilly: Tirzepatide/Mounjaro Lily initially developed Tirzepatide as a dual agonist, with a half-life of around 5 days, for the treatment of T2DM
Regular exercise not only helps maintain a healthy weight but also promotes regular bowel function, reducing the likelihood of straining during bowel movements
Others have strong mechanistic evidence with clinical data still emerging
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