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In a pre-clinical trial, patients with moderate PD who received subcutaneous injection of 2 mg exenatide once a week had an advantage of 3.5 points in the mds-updrs exercise scale over the placebo group (74)

Consequently, on top of the beneficial effect of weight loss caused by GLP-1 analogues these drugs also cause a substantial reduction of the glycemic load (GL = carbohydrate intake X Glycemic index), which per se reduces hyperinsulinemia and causes weight loss [22], reduce diabetes risk [23], inflammation [24], and cardiovascular risk [25]