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Yes, you can generally drink coffee while taking semaglutide

However, no clinical trials have evaluated this combination, so added benefit is unclear

Muscatelli F, Abrous DN, Massacrier A, Boccaccio I, Le Moal M, Cau P, et al

What are the side effects of Ozempic and other GLP agonists

These are conversations you should be having with your prescribing provider, and the quality of that interaction matters as much as the price of the medication