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Copper delivery through skin can provide beneficial effects but its potential to induce skin irritation reactions is often overlooked
doi:10.1371/journal.pone.0135268
Use raw heart-rate change rather than placebo-subtracted when assessing drug-attributable load: the placebo arm shows real cardiovascular adaptation from weight loss and lifestyle counseling, so subtraction over-corrects
The documented research protocol is once daily: 150 mcg from the 10 mg vial, or 2.5 mg from the 50 mg vial
Others may notice gradual improvement over the first few days
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