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Melatonin and the theories of aging: a critical appraisal of melatonin's role in [PMID: 24112071] Laboratory literature summary: Melatonin and the theories of aging: a critical appraisal of melatonin's role in aging-biology mechanisms

At high doses (over 3 g), nausea, stomach cramps, diarrhea, and a "fishy body odor" (trimethylamine accumulation) can occur

Effects of high glucose on integrin activity and fibronectin matrix assembly by mesangial cells

This leads to a reduction in calorie intake, supporting weight loss

[32] [33] The efficacy of melatonin in disease treatment has been the subject of limited trials, with most available data deriving from small-scale, preliminary studies