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Tissue losses and metabolic adaptations both contribute to the reduction in resting metabolic rate following weight loss
1,2 If initiating a GLP-1 RA in a patient with T2D for glucose-lowering effect and/or for organ protection in a patient on background DPP-4 inhibitor therapy, it is recommended that the DPP-4 inhibitor be discontinued
For instance, they may reduce your body's sensitivity to insulin and increase your blood sugar
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