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Most compounded semaglutide remains safe and effective if left out of the fridge for up to 30 days, but it will depend on the exact formulation of your medication

If youre eating fewer calories but those calories come primarily from processed foods, refined sugars, or alcohol, your results will likely stall

Magnesium (200-400 mg daily) is depleted when food intake drops and is lost through gastrointestinal side effects like diarrhea

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Additionally, some IBS patientsparticularly those with IBS-C (constipation-predominant)may experience worsening of slow transit and constipation when starting GLP-1 medications, as these drugs naturally slow gastric emptying