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Vitamin C : This essential nutrient not only acts as an antioxidant itself but also helps regenerate glutathione

Additional information Peer review information Nature Chemical Biology thanks Dohoon Kim and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

230 TANs expressing CCL4 recruit SSP1 + macrophages, while TANs expressing PD-L1 inhibit T cell cytotoxicity in liver tumors, highlighting potential therapeutic targets among pro-tumor TANs

CagriSema cagrilintide 2.4 mg plus semaglutide 2.4 mg was submitted to the FDA on 18 December 2025 for chronic weight management, with the agency expected to review it during 2026

These mtROS suppress autophagic clearance by oxidatively inactivating the IRS-1/PI3K pathway [413], while simultaneously activating HIF-1 to promote glycolysis, creating a nutrient-rich microenvironment for MTB