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Phosphorylation of Y1135 and Y1131 destabilises the autoinhibitory conformation of the a-loop, whereas phosphorylation of Y1136 stabilises the catalytically optimised conformation of it (Favelyukis et al, 2001)
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View Study [4]"FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation" Communications Biology (Nature Portfolio), 2025 Finding: In keloid scar cells, FOXO4-DRI triggered death of senescent fibroblasts by pushing phosphorylated p53 (at serine 15) out of the nucleus, supporting a possible role in scar-related research
[2] Weiss JB, Phillips CJ, Malin EW, Gorantla VS, Harding JW, Salgar SK
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