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When administered under licensed medical supervision using pharmaceutical-grade compounds, the combination has a well-documented safety profile

[23] The duration of therapy (number of weeks or months of injections) is also determined on a case-by-case basis

The one human trial that will measure tolerability directly has not started reporting it is only recruiting (planned 2026), studies a topical gel on small standardized wounds , and lists safety as a secondary, not primary, outcome (NCT07437586)

10.1016/j.cell.2005.03.036 Cell 32 XieZ.ZhangD.ChungD.TangZ.HuangH.DaiL.et al (2016)

These sizes describe the syringe barrel capacity, not the needle thickness or needle length