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Pathological oral mucosal melanin hyperpigmentations include those related to tobacco smoke, to certain systemic diseases or syndromes, to inflammatory processes, to certain drugs, and to developmental, benign, or malignant changes in melanocytes [4, 6, 1013]
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Lower blood pressure and BW loss correlate independently with SGLT2 inhibitor treatment, with the effect of both GLP-1RA and SGLT2 inhibitors being significantly greater on systolic BP than on diastolic BP [4]
These associations with non-invasive biomarkers such as ELF have not been established
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