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Temporal measurements of class IA PI3K activation identify conserved, dynamic encoding of growth factor signals Using different cellular model systems (human HeLa cervical cancer cells, human A549 lung adenocarcinoma cells, immortalized mouse embryonic fibroblasts (MEFs)) with or without endogenous functional PI3K, we next tested the hypothesis that the identity of different growth factors was captured in the cellular dynamics of PIP 3 /PI(3,4)P 2

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The reasons are disputed

Dual pathway: cagrilintide is a long-acting amylin analog, semaglutide is a GLP-1 receptor agonist, both studied for appetite and glycemic signaling