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Melanosis coli is a darkening of the colonic mucosa caused by the accumulation of lipofuscin particles within the macrophages of the lamina propria of the colonic mucosas a result of long term exposure to anthraquinone-containing laxatives

observed, in a murine model of selective podocyte damage, that massive filtration of liver-derived AGT led to enhanced renal ANG II content although renal renin was suppressed (39)

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